Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks.

ABSTRACT: Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell types. Here we examine how specific transcriptomic types of mouse prefrontal cortex (PFC) projection neurons relate to axonal projections and encoding properties across multiple cognitive tasks. We found that most types projected to multiple targets, and most targets received projections from multiple types, except PFC→PAG (periaqueductal gray). By comparing Ca²⁺ activity of the molecularly homogeneous PFC→PAG type against two heterogeneous classes in several two-alternative choice tasks in freely moving mice, we found that all task-related signals assayed were qua

SUBMITTER: Lui JH 

PROVIDER: S-EPMC7935083 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature