Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.

ABSTRACT: Transmitter signalling is the universal chemical language of any nervous system, but little is known about its early evolution. Here, we summarize data about the distribution and functions of neurotransmitter systems in basal metazoans as well as outline hypotheses of their origins. We explore the scenario that neurons arose from genetically different populations of secretory cells capable of volume chemical transmission and integration of behaviours without canonical synapses. The closest representation of this primordial organization is currently found in Placozoa, disk-like animals with the simplest known cell composition but complex behaviours. We propose that injury-related signalling was the evolutionary predecessor for integrative functions of early transmitters such as nitric oxide

SUBMITTER: Moroz LL 

PROVIDER: S-EPMC7935107 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature