Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa.

ABSTRACT:

Background

We have previously demonstrated that eosinophil-associated processes underlie some of the differences in clinical presentation among patients with Loa loa infection prior to therapy and that some posttreatment adverse events appear to be dependent on eosinophil activation.

Methods

We first conducted a retrospective review of 204 patients (70 microfilaria [MF] positive/134 negative) with Loa loa both before and following definitive therapy. We then measured filarial-specific antibodies, eosinophil- and Th2-associated cytokines, and eosinophil granule proteins in their banked serum prior to and at 1 year following definitive treatment. We also evaluated the influence of pretreatment corticosteroids and/or apheresis in altering the efficacy of treatment.

Results</

SUBMITTER: Herrick JA 

PROVIDER: S-EPMC7935394 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature