Longitudinal evaluation of upper motor neuron burden scales in primary lateral sclerosis.

ABSTRACT:

Objective

To assess whether published scales for measuring upper motor neuron burden (UMNB) show longitudinal change in patients with primary lateral sclerosis (PLS). Design: Retrospective calculation of three UMNB scales on a prospectively collected dataset from 53 patients with PLS enrolled in a longitudinal natural history study with at least 2 evaluation visits. UMNB scales were calculated according to their published descriptions. Non-linear trends over time of UMNB scale scores and slopes were calculated for each patient and correlations between UMNB scores and clinical measures were assessed. Results: All three UMNB scales exhibited increasing scores over the first 7.8 years of symptoms, with a flattening in slope after approximately 8 years. A scale used in im

SUBMITTER: Floeter MK 

PROVIDER: S-EPMC7935469 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature