Ontology highlight
ABSTRACT:
SUBMITTER: Thakore P
PROVIDER: S-EPMC7935492 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
eLife 20210226
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating retrograde signal that dilates upstream parenchymal arterioles to initiate functional hyperemia. We find that activation of TRPA1 in capillary beds and post-arteriole transitional segments with mural cell coverage initiates retrograde signals tha ...[more]