Terminally Differentiated CD4⁺ T Cells Promote Myocardial Inflammaging.

ABSTRACT: The cardiovascular and immune systems undergo profound and intertwined alterations with aging. Recent studies have reported that an accumulation of memory and terminally differentiated T cells in elderly subjects can fuel myocardial aging and boost the progression of heart diseases. Nevertheless, it remains unclear whether the immunological senescence profile is sufficient to cause age-related cardiac deterioration or merely acts as an amplifier of previous tissue-intrinsic damage. Herein, we sought to decompose the causality in this cardio-immune crosstalk by studying young mice harboring a senescent-like expanded CD4⁺ T cell compartment. Thus, immunodeficient NSG-DR1 mice expressing HLA-DRB1*01:01 were transplanted with human CD4⁺ T cells purified from matching dono

SUBMITTER: Delgobo M 

PROVIDER: S-EPMC7935504 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature