Pathological evaluation of tumor grade for salivary adenoid cystic carcinoma: A proposal of an objective grading system.

ABSTRACT: Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of the solid tumor component in AdCC specimens is an important index. However, the "solid tumor component" has not been well defined. Salivary AdCC cases (N = 195) were collected after a central pathology review. We introduced a novel criterion for solid tumor component, minAmax (minor axis maximum). The largest solid tumor nest in each AdCC case was histologically screened, the maximum oval fitting the solid nest was estimated, and the length of the minor axis of the oval (minAmax) was measured. The prognostic cutoff for the minAmax was determined using training and validation cohorts. All cases were evaluated

SUBMITTER: Morita N 

PROVIDER: S-EPMC7935776 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature