Predictive and prognostic transcriptomic biomarkers in soft tissue sarcomas.

ABSTRACT: Soft tissue sarcomas (STS) are rare and heterogeneous tumours comprising over 80 different histological subtypes. Treatment options remain limited in advanced STS with high rates of recurrence following resection of localised disease. Prognostication in clinical practice relies predominantly on histological grading systems as well as sarcoma nomograms. Rapid developments in gene expression profiling technologies presented opportunities for applications in sarcoma. Molecular profiling of sarcomas has improved our understanding of the cancer biology of these rare cancers and identified potential novel therapeutic targets. In particular, transcriptomic signatures could play a role in risk classification in sarcoma to aid prognostication. Unlike other solid and haematological malignancies, tra

SUBMITTER: Merry E 

PROVIDER: S-EPMC7935908 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature