Ontology highlight
ABSTRACT:
SUBMITTER: Rosa BA
PROVIDER: S-EPMC7935909 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Rosa Bruce A BA Ahmed Mushtaq M Singh Dhiraj K DK Choreño-Parra José Alberto JA Cole Journey J Jiménez-Álvarez Luis Armando LA Rodríguez-Reyna Tatiana Sofía TS Singh Bindu B Gonzalez Olga O Carrion Ricardo R Schlesinger Larry S LS Martin John J Zúñiga Joaquín J Mitreva Makedonka M Kaushal Deepak D Khader Shabaana A SA
Communications biology 20210305 1
SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 infection, we have characterized the transcriptional signatures induced in the lungs of juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are significantly induced in macaque infected lungs, while pathways associated with collagen forma ...[more]