Feasibility and beneficial effects of an early goal directed therapy after cardiac arrest: evaluation by conductance method.

ABSTRACT: Although beneficial effects of an early goal directed therapy (EGDT) after cardiac arrest and successful return of spontaneous circulation (ROSC) have been described, clinical implementation in this period seems rather difficult. The aim of the present study was to investigate the feasibility and the impact of EGDT on myocardial damage and function after cardiac resuscitation. A translational pig model which has been carefully adapted to the clinical setting was employed. After 8 min of cardiac arrest and successful ROSC, pigs were randomized to receive either EGDT (EGDT group) or therapy by random computer-controlled hemodynamic thresholds (noEGDT group). Therapeutic algorithms included blood gas analysis, conductance catheter method, thermodilution cardiac output and transesophageal echo

SUBMITTER: Broch O 

PROVIDER: S-EPMC7935910 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature