Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates.

ABSTRACT: TG2 is a multifunctional enzyme involved in several cellular processes and has emerging as a potential regulator of gene expression. In this regard, we have recently shown that TG2 is able to activate HSF1, the master transcriptional regulator of the stress-responsive genes; however, its effect on the overall gene expression remains unclear. To address this point, we analyzed, by RNA-seq, the effect of TG2 on the overall transcriptome as well as we characterized the TG2 interactome in the nucleus. The data obtained from these omics approaches reveal that TG2 markedly influences the overall cellular transcriptome profile and specifically the Wnt and HSF1 pathways. In particular, its ablation leads to a drastic downregulation of many key members of these pathways. Interestingly, we found tha

SUBMITTER: Rossin F 

PROVIDER: S-EPMC7935911 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature