Reward Functioning Abnormalities in Adolescents at High Familial Risk for Depressive Disorders.

ABSTRACT:

Background

A parental history of major depressive disorder (MDD) is an established risk factor for MDD in youth, and clarifying the mechanisms related to familial risk transmission is critical. Aberrant reward processing is a promising biomarker of MDD risk; accordingly, the aim of this study was to test behavioral measures of reward responsiveness and underlying frontostriatal resting activity in healthy adolescents both with (high-risk) and without (low-risk) a maternal history of MDD.

Methods

Low-risk and high-risk 12- to 14-year-old adolescents completed a probabilistic reward task (n = 74 low-risk, n = 27 high-risk) and a resting-state functional magnetic resonance imaging scan (n = 61 low-risk, n = 25 high-risk). Group differences in response bias toward reward and res

SUBMITTER: Belleau EL 

PROVIDER: S-EPMC7936004 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature