Expanding Our Understanding of Ovarian Cancer Risk: The Role of Incomplete Pregnancies.

ABSTRACT:

Background

Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.

Methods

A pooled analysis of 10 470 invasive epithelial ovarian cancer cases and 16 942 controls was conducted. Odds ratios (ORs) and 95% confidence intervals (CIs) for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race and ethnicity, age, and

SUBMITTER: Lee AW 

PROVIDER: S-EPMC7936053 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature