"When Offered to Participate": A Systematic Review and Meta-Analysis of Patient Agreement to Participate in Cancer Clinical Trials.

ABSTRACT:

Background

Patient participation in clinical trials is vital for knowledge advancement and outcomes improvement. Few adult cancer patients participate in trials. Although patient.decision-making about trial participation has been frequently examined, the participation rate for patients actually offered a trial is unknown.

Methods

A systematic review and meta-analysis using 3 major search engines was undertaken. We identified studies from January 1, 2000, to January 1, 2020, that examined clinical trial participation in the United States. Studies must have specified the numbers of patients offered a trial and the number enrolled. A random effects model of proportions was used. All statistical tests were 2-sided.

Results

We identified 35 studies (30 about treatment tria

SUBMITTER: Unger JM 

PROVIDER: S-EPMC7936064 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature