Association between antecedent statin use and severe disease outcomes in COVID-19: A retrospective study with propensity score matching.

ABSTRACT:

Background

Statins have been associated with a reduction in inflammatory markers and improved endothelial function. Whether statins offer any benefit in COVID-19 needs to be elucidated.

Objective

To determine the association between antecedent statin use and severe disease outcomes among COVID-19 patients.

Methods

A retrospective cohort study on 1014 patients with confirmed COVID-19 diagnosis. Outcomes were mortality, need for mechanical ventilation, and intensive care admission. Patients were classified into statin-users vs statin non-users based on antecedent use of statins. Multivariable regression analysis was performed adjusting for confounders such as age, sex, race, BMI, smoking, insurance, and comorbidities. Propensity score matching was performed to achieve a

SUBMITTER: Lohia P 

PROVIDER: S-EPMC7936125 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature