Activation of AMP-activated protein kinase signaling pathway ameliorates steatosis in laying hen hepatocytes.

ABSTRACT: The fatty liver hemorrhage syndrome in laying hens is a disease of lipid metabolism disorders. Importantly, energy sensor AMP-activated protein kinase (AMPK) plays an essential role in homeostasis regulation of liver lipid. The current research aims to investigate the relationship between AMPK signaling pathway and lipid metabolism in laying hen hepatocytes and explore the underlying mechanisms. The steatotic hepatocytes model of laying hen was established and treated with AMPK agonist AICAR and inhibitor compound C. The results showed that the levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol significantly declined while high-density lipoprotein cholesterol level increased in the AICAR-treated steatosis group compared with the steatosis group. Furthermore,

SUBMITTER: Zhang K 

PROVIDER: S-EPMC7936166 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature