Synergistic effect of hypocrellin B and curcumin on photodynamic inactivation of Staphylococcus aureus.

ABSTRACT: Antimicrobial photodynamic inactivation (aPDI) serves as a new approach to control the growth of foodborne bacteria. It remains elusive if the photodynamic efficacy of hypocrellin B (HB) can be potentiated by joint action with curcumin. In this study, we measured the survival rate of Staphylococcus aureus strains under the varying photodynamic conditions. According to our data, a maximum of 5-6 log₁₀ decrease of bacterial survival can be achieved under the tested conditions (500 nM, 9 J cm^-2 ). Regarding the bactericidal mechanisms, HB-based aPDI disrupted the membrane integrity of staphylococcal cells, probably owing to the stimulated reactive oxygen species (ROS). In addition, aPDI disrupted the enzymatic activities of bacterial antioxidant proteins and caused the l

SUBMITTER: Li Y 

PROVIDER: S-EPMC7936292 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature