Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans.

ABSTRACT: Candida albicans is a common human fungal pathogen. The previous study revealed that quinone compounds showed antimicrobial activity against C. albicans by inhibiting cell growth. However, it was unclear whether quinones have other antifungal effects against C. albicans in addition to fungicidal effects. In this study, we assessed the inhibitory activity of a total of 25 quinone compounds against C. albicans morphological transition, which is essential for the pathogenicity of C. albicans. Several quinones exhibited strong inhibition of mycelium formation by C. albicans SC5314. Three leading compounds, namely hypocrellins A, B and C, also exhibited marked attenuation of C. albicans SC5314 virulence in both human cell lines and mouse infection models. These three compounds significantly sup

SUBMITTER: Song S 

PROVIDER: S-EPMC7936304 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature