The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens.

ABSTRACT:

Introduction

Although myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN) - including chronic myeloid leukemia (CML) - and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are largely clinically distinct myeloid malignancies, epidemiological studies rarely examine them separately and often combine them with lymphoid malignancies, limiting possible etiological interpretations for specific myeloid malignancies.

Methods

We systematically evaluated the epidemiological literature on the four chemical agents (1,3-butadiene, formaldehyde, benzene, and tobacco smoking, excluding pharmaceutical, microbial and radioactive agents, and pesticides) classified by the International Agency for Research on Cancer as having sufficient epidemi

SUBMITTER: Mundt KA 

PROVIDER: S-EPMC7936449 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature