Association between alcohol consumption and oesophageal microbiota in oesophageal squamous cell carcinoma.

ABSTRACT:

Background

Microbiota has been reported to play a role in cancer patients. Nevertheless, little is known about the association between alcohol consumption and resultant changes in the diversity and composition of oesophageal microbiota in oesophageal squamous cell carcinoma (ESCC).

Methods

We performed a hospital-based retrospective study of 120 patients with pathologically diagnosed primary ESCC. The relevant information for all study participants were collected through a detailed questionnaire. The differences in adjacent tissues between non-drinkers and drinkers were explored using 16S rRNA gene sequencing. Raw sequencing data were imported into QIIME 2 to analyse the diversity and abundance of microbiota. Linear discriminant analysis effect size (LEfSe) and unconditional

SUBMITTER: Rao W 

PROVIDER: S-EPMC7936487 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature