Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines. Previous reports highlighted a relationship between IL-21and the pathogenesis of RA. Although elevated IL-21 levels have been reported in RA patients, the association of common IL-21 genetic variants with a predisposition to RA development in the Chinese population lacks.

Materials and methods

Five hundred and fourteen Chinese subjects (healthy controls: 303 and rheumatoid arthritis patients: 211) were enrolled in the study. Clinical data of patients were collected from medical records, and patients were treated as per the guidelines. Common single nucleotide polymorphisms in the IL-21 gene (rs907715, rs2

SUBMITTER: Hao Y 

PROVIDER: S-EPMC7936495 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature