Improved gene delivery to K-562 leukemia cells by lipoic acid modified block copolymer micelles.

ABSTRACT: Although there has been substantial progress in the research field of gene delivery, there are some challenges remaining, e.g. there are still cell types such as primary cells and suspension cells (immune cells) known to be difficult to transfect. Cationic polymers have gained increasing attention due to their ability to bind, condense and mask genetic material, being amenable to scale up and highly variable in their composition. In addition, they can be combined with further monomers exhibiting desired biological and chemical properties, such as antioxidative, pH- and redox-responsive or biocompatible features. By introduction of hydrophobic monomers, in particular as block copolymers, cationic micelles can be formed possessing an improved chance of transfection in otherwise challenging c

SUBMITTER: Richter F 

PROVIDER: S-EPMC7936509 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature