Serum melatonin concentration in critically ill patients randomized to sedation or non-sedation.

ABSTRACT:

Background

Abolished circadian rhythm is associated with altered cognitive function, delirium, and as a result increased mortality in critically ill patients, especially in those who are mechanically ventilated. The causes are multifactorial, of which changes in circadian rhythmicity may play a role. Melatonin plays a crucial role as part of the circadian and sleep/wake cycle. Whether sedation effects circadian regulation is unknown. Hence, the objective of this study was to evaluate the melatonin concentration in critically ill patients randomized to sedation or non-sedation and to investigate the correlation with delirium.

Methods

All patients were included and randomized at the intensive care unit at the hospital of southwest Jutland, Denmark. Seventy-nine patients comple

SUBMITTER: Oxlund J 

PROVIDER: S-EPMC7936862 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature