Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.

ABSTRACT:

Purpose

Rare genetic conditions like Down syndrome (DS) are historically understudied. Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is unknown how the COVID-19 pandemic affects individuals with DS. Herein, we report an analysis of individuals with DS who were hospitalized with COVID-19 in New York, New York, USA.

Methods

In this retrospective, dual-center study of 7246 patients hospitalized with COVID-19, we analyzed all patients with DS admitted in the Mount Sinai Health System and Columbia University Irving Medical Center. We assessed hospitalization rates, clinical characteristics, and outcomes.

Results

We identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients w

SUBMITTER: Malle L 

PROVIDER: S-EPMC7936948 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature