Development, diagnostic performance, and interobserver agreement of a ¹⁸F-flurpiridaz PET automated perfusion quantitation system.

ABSTRACT:

Background

Computerized methodologies standardize the myocardial perfusion imaging (MPI) interpretation process.

Methods

To develop an automated relative perfusion quantitation approach for ¹⁸F-flurpiridaz, PET MPI studies from all phase III trial participants of ¹⁸F-flurpiridaz were divided into 3 groups. Count distributions were obtained in N = 40 normal patients undergoing pharmacological or exercise stress. Then, N = 90 additional studies were selected in a derivation group. Following receiver operating characteristic curve analysis, various standard deviations below the mean normal were used as cutoffs for significant CAD, and interobserver variability determined. Finally, diagnostic performance was compared between blinded visual readers and blind

SUBMITTER: Packard RRS 

PROVIDER: S-EPMC7936994 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature