Impact of overweight and obesity on patient-reported health-related quality of life in systemic lupus erythematosus.

ABSTRACT:

Objectives

Associations between BMI and health-related quality of life (HRQoL) in SLE have been implied, but data are scarce. We determined the impact of overweight and obesity on HRQoL in a large SLE population.

Methods

We pooled cross-sectional baseline data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (N = 1684). HRQoL was evaluated using the 36-item Short Form Health Survey (SF-36), Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and the European Quality of Life 5-dimension questionnaire (EQ-5D). Comparisons between BMI groups were conducted using the Mann-Whitney U test and adjustments using linear regression. Clinical relevance was determined by minimal clinically important differences (MCIDs).

Results

In total, 43.2%

SUBMITTER: Gomez A 

PROVIDER: S-EPMC7937019 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature