Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.

ABSTRACT:

Objective

To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics.

Methods

This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which macroscopically unaffected (preserved, n = 56) and lesioned (n = 45) OA articular cartilage were collected [Research Arthritis and Articular Cartilage (RAAK) study]. Unsupervised hierarchical clustering analysis on preserved cartilage transcriptome followed by clinical data integration was performed. Protein-protein interaction (PPI) followed by pathway enrichment analysis were done for genes significant differentially expressed between subgroups w

SUBMITTER: Coutinho de Almeida R 

PROVIDER: S-EPMC7937023 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature