HIR V2: a human interactome resource for the biological interpretation of differentially expressed genes via gene set linkage analysis.

ABSTRACT: To facilitate biomedical studies of disease mechanisms, a high-quality interactome that connects functionally related genes is needed to help investigators formulate pathway hypotheses and to interpret the biological logic of a phenotype at the biological process level. Interactions in the updated version of the human interactome resource (HIR V2) were inferred from 36 mathematical characterizations of six types of data that suggest functional associations between genes. This update of the HIR consists of 88 069 pairs of genes (23.2% functional interactions of HIR V2 are in common with the previous version of HIR), representing functional associations that are of strengths similar to those between well-studied protein interactions. Among these functional interactions, 57% may represent pro

SUBMITTER: Guo WP 

PROVIDER: S-EPMC7937034 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature