Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease.

ABSTRACT:

Background

Regenerative therapies to mitigate Alzheimer's disease (AD) neuropathology have shown very limited success. In the recent era, extracellular vesicles (EVs) derived from multipotent and pluripotent stem cells have shown considerable promise for the treatment of dementia and many neurodegenerative conditions.

Methods

Using the 5xFAD accelerated transgenic mouse model of AD, we now show the regenerative potential of human neural stem cell (hNSC)-derived EVs on the neurocognitive and neuropathologic hallmarks in the AD brain. Two- or 6-month-old 5xFAD mice received single or two intra-venous (retro-orbital vein, RO) injections of hNSC-derived EVs, respectively.

Results

RO treatment using hNSC-derived EVs restored fear extinction memory consolidation and reduced

SUBMITTER: Apodaca LA 

PROVIDER: S-EPMC7937214 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature