APE1 may influence CD4+ naive T cells on recurrence free survival in early stage NSCLC.

ABSTRACT:

Background

It was demonstrated that multifunctional protein APE1 (Apurinic/apyrimidinic endonuclease 1) is closely related to tumor immune microenvironment in a number of investigations, Meanwhile, the abundance of tumor infiltrating lymphocytes (TILs) has been shown as a prognosis indicator in some researches. However, it remains unclear whether APE1 is involved in the process of TILs affecting the prognosis of patients. To this end, we investigated the associations between APE1 and TILs in non-small cell lung cancer (NSCLC) and explored whether APE1 would influence the associations of CD4⁺ T cells infiltration with the prognosis of patients.

Methods

Genome-wide expression datasets were obtained from the Gene Expression Omnibus (GEO) public database under accessi

SUBMITTER: Li Y 

PROVIDER: S-EPMC7937314 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature