Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics.
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ABSTRACT:
SUBMITTER: Twomey JD
PROVIDER: S-EPMC7937597 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics.
Twomey Julianne D JD Zhang Baolin B
The AAPS journal 20210307 2
Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many cancer indications. This review provides an update on ICIs approved by the Food and Drug Administration (FDA), with focus on monoclonal antibodies that target the programmed cell death 1 (PD-1) or its ligand, PD-1 ligand 1 (PD-L1), including information on their clinical indications and associated companion diagnostics. The information is further discussed with strategies for identifying predictive biomarkers t ...[more]
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