Phenotypic Characterization of CD4⁺ T Lymphocytes in Periportal Fibrosis Secondary to Schistosomiasis.

ABSTRACT: Schistosomiasis is a parasitic disease that affects about 166 million people around the world. It is estimated that 5%-10% of individuals with schistosomiasis develop severe forms of the disease, which are characterized by pulmonary hypertension, ascites, periportal fibrosis, and other significant complications. The chronic phase of the disease is associated with a Th2 type immune response, but evidence also suggests there are roles for Th1 and Th17 in the development of severe disease. The aim of this study was to evaluate the CD4⁺ T lymphocyte profile of patients with different degrees of periportal fibrosis secondary to schistosomiasis. These individuals had been treated for schistosomiasis, but since they live in a S. mansoni endemic area, they are at risk of reinfect

SUBMITTER: Santana JB 

PROVIDER: S-EPMC7937650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature