Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

ABSTRACT: Epinephrine is a hormone secreted primarily by medullary cells of the adrenal glands which regulates permeability of blood-brain barrier (BBB). Recent studies showed signaling by epinephrine/epinephrine receptor in T cells is involved in autoimmune diseases. Nevertheless, the production of epinephrine by T cells and its pathogenic function in T cells are not well investigated. Our results show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated T_H17 cells and in tissue-resident T_H17 cells. Indeed, expression levels of enzymes involved in epinephrine production are higher in T_H17 cells from animals after EAE induction. The induction of PNMT was not observe

SUBMITTER: Yang P 

PROVIDER: S-EPMC7937652 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature