Alcohol Intake Is Associated With Elevated Serum Levels of Selenium and Selenoprotein P in Humans.

ABSTRACT: Selenoprotein P is a hepatokine with antioxidative properties that eliminate a physiologic burst of reactive oxygen species required for intracellular signal transduction. Serum levels of selenoprotein P are elevated during aging and in people with type 2 diabetes, non-alcoholic fatty liver disease, and hepatitis C. However, how serum levels of full-length selenoprotein P are regulated largely remains unknown, especially in the general population. To understand the significance of serum selenoprotein P levels in the general population, we evaluated intrinsic and environmental factors associated with serum levels of full-length selenoprotein P in 1,183 subjects participating in the Shika-health checkup cohort. Serum levels of selenium were positively correlated with liver enzymes and alcoho

SUBMITTER: Isobe Y 

PROVIDER: S-EPMC7937717 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature