Investigation of Cerebral White Matter Changes After Spinal Cord Injury With a Measure of Fiber Density.

ABSTRACT: Remote neurodegenerative changes in supraspinal white matter (WM) can manifest after central lesions such as spinal cord injury (SCI). The majority of diffusion tensor imaging (DTI) studies use traditional metrics such as fractional anisotropy (FA) and mean diffusivity (MD) to investigate microstructural changes in cerebral WM after SCI. However, interpretation of FA readouts is often challenged by inherent limitations of the tensor model. Recent developments in novel diffusion markers, such as fiber density (FD), allows more accurate depictions of WM pathways and has shown more reliable quantification of WM alterations compared to FA in recent studies of neurological diseases. This study investigated if FD provides useful characterization of supraspinal WM integrity after SCI in addition

SUBMITTER: Huynh V 

PROVIDER: S-EPMC7937730 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature