Mechanism of Lipid Accumulation through PAR2 Signaling in Diabetic Male Mice.

ABSTRACT:

Background

Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have not yet been examined. In liver, Forkhead box O1 (FoxO1) activity induces peroxisome proliferator-activated receptor γ (PPARγ), leading to accumulation of lipids and hyperlipidemia. Hyperlipidemia significantly influence hepatic steatoses, but the mechanisms underlying PAR2 signaling are complex and have not yet been elucidated.

Methods

To examine the modulatory action of FoxO1 and its altered interaction with PPARγ, we utilized db/db mice and PAR2-knockout (KO) mice administered with high-fat diet (HFD).

Results

Here, we demonstrated that PAR2 was overexp

SUBMITTER: Kim DH 

PROVIDER: S-EPMC7937841 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature