Effect of Initial Aflibercept, Laser, or Observation on Low-Contrast Visual Acuity in Eyes With Diabetic Macular Edema and Good Vision: Ancillary Study Within a Randomized Clinical Trial.

ABSTRACT:

Purpose

To describe 2.5% low-contrast visual acuity (VA) among eyes with good vision despite center-involved diabetic macular edema and compare changes after initial management with aflibercept, laser, or observation.

Methods

This was an ancillary study within a multicenter randomized clinical trial (DRCR Retina Network Protocol V). Participants had diabetes and 1 study eye with center-involved diabetic macular edema and a VA of 20/25 or better randomly assigned to aflibercept (n = 112), focal/grid laser (n = 146), or observation (n = 129). Eyes in the laser and observation groups received aflibercept if VA met prespecified worsening criteria.

Results

Participants had median age of 60 years, 37% were female and 70% were non-Hispanic White. At baseline, the mean ± stan

SUBMITTER: Beaulieu WT 

PROVIDER: S-EPMC7937990 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature