Functional Relevance of Hyper-Reflectivity in Macular Telangiectasia Type 2.

ABSTRACT:

Purpose

The purpose of this study was to quantify hyper-reflective lesions on en face optical coherence tomography (OCT) and study its functional relevance in macular telangiectasia type 2 (MacTel).

Design

This was a retrospective, cross-sectional cohort study.

Methods

Baseline image and functional data from participants of a phase II clinical trial (NCT01949324) that studied the effect of Ciliary Neurotrophic Factor in patients with MacTel were analyzed. The projection of hyper-reflectivity within different layers on OCT was used to generate an en face view and measure the en face size of hyper-reflectivity. Ellipsoid zone (EZ)-loss was additionally evaluated, and en face images were superimposed onto microperimetry sensitivity maps, allowing to estimate mean retinal

SUBMITTER: Tzaridis S 

PROVIDER: S-EPMC7937992 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature