Comparison of the equilibrium, kinetic and water exchange properties of some metal ion-DOTA and DOTA-bis(amide) complexes.

ABSTRACT: The 1,7-diacetate-4,10-diacetamide substituted 1,4,7,10-tetraazacyclododecane structural unit is common to several responsive Magnetic Resonance Imaging (MRI) contrast agents (CAs). While some of these complexes (agents capable of sensing fluctuations in Zn²⁺, Ca²⁺ etc. ions) have already been tested in vivo, the detailed physico-chemical characterization of such ligands have not been fully studied. To fill this gap, we synthesized a representative member of this ligand family possessing two acetate and two n-butylacetamide pendant side-arms (DO2A2M^nBu = 1,4,7,10-tetraazacyclodoecane-1,7-di(acetic acid)-4,10-di(N-butylacetamide)), and studied its complexation properties with some essential metal and a few lanthanide(III) (Ln(III)) ions. Our studies revealed

SUBMITTER: Tircso G 

PROVIDER: S-EPMC7937998 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature