Reliability of Retinal Pathology Quantification in Age-Related Macular Degeneration: Implications for Clinical Trials and Machine Learning Applications.

ABSTRACT:

Purpose

To investigate the interreader agreement for grading of retinal alterations in age-related macular degeneration (AMD) using a reading center setting.

Methods

In this cross-sectional case series, spectral-domain optical coherence tomography (OCT; Topcon 3D OCT, Tokyo, Japan) scans of 112 eyes of 112 patients with neovascular AMD (56 treatment naive, 56 after three anti-vascular endothelial growth factor injections) were analyzed by four independent readers. Imaging features specific for AMD were annotated using a novel custom-built annotation platform. Dice score, Bland-Altman plots, coefficients of repeatability, coefficients of variation, and intraclass correlation coefficients were assessed.

Results

Loss of ellipsoid zone, pigment epithelium detachment, subr

SUBMITTER: Muller PL 

PROVIDER: S-EPMC7938003 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature