Characteristics of Patients with End-Stage Kidney Disease in ADPKD.

ABSTRACT:

Introduction

Cystic expansion damaging the parenchyma is thought to lead to end-stage kidney disease (ESKD) in autosomal dominant polycystic kidney disease (ADPKD). Here we characterized genotypic and phenotypic attributes of ADPKD at time of ESKD.

Methods

This is a retrospective cross-sectional study of patients with ADPKD with ESKD evaluated at Mayo Clinic with available abdominal computed tomography (CT) or magnetic resonance imaging (MRI). Kidney volumes were measured (total kidney volume adjusted for height [HtTKV]), Mayo Image Class (MIC) calculated, ADPKD genotype determined, and clinical and laboratory features obtained from medical records.

Results

Differences in HtTKV at ESKD were associated with patient age and sex; older patients and women had smaller HtTK

SUBMITTER: Shukoor SS 

PROVIDER: S-EPMC7938061 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature