A Systematic Review and Meta-Analysis on Effects of Bicarbonate Therapy on Kidney Outcomes.

ABSTRACT:

Aim

Preclinical studies suggest treatment of metabolic acidosis may slow chronic kidney disease (CKD) progression. This systematic review aimed to summarize evidence from randomized controlled trials (RCTs) concerning the benefits and risks of bicarbonate therapy on kidney outcomes.

Methods

Medline, EMBASE, and Cochrane databases were searched for RCTs with ≥3 months' follow-up in patients with CKD (estimated glomerular filtration rate [eGFR] ≤60 ml/min per 1.73 m² and/or proteinuria) comparing the effects of sodium bicarbonate with placebo/no study medication on kidney outcomes. The primary outcome was change from baseline to last measurement in kidney function measured as either eGFR or creatinine clearance. Treatment effects were summarized using random-effects

SUBMITTER: Hultin S 

PROVIDER: S-EPMC7938083 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature