Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis.

ABSTRACT: Previous studies have reported the association between multiple genetic variants in the enamel-formation genes and the risk of dental caries with inconsistent results. We performed a systematic literature search of the PubMed, Cochrane Library, HuGE and Google Scholar databases for studies published before March 21, 2020 and conducted meta-, gene-based and gene-cluster analysis on the association between genetic variants in the enamel-formation genes and the risk of dental caries. We identified 21 relevant publications including a total of 24 studies for analysis. The genetic variant rs17878486 in AMELX was significantly associated with dental caries risk (OR = 1.40, 95% CI: 1.02-1.93, P = 0.037). We found no significant association between the risk of dental caries with rs12

SUBMITTER: Li X 

PROVIDER: S-EPMC7938150 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature