Network pharmacology-based analysis of the role of tacrolimus in liver transplantation.

ABSTRACT:

Background

Tacrolimus is a powerful immunosuppressant and has been widely used in organ transplantation. In order to further explore the role of tacrolimus in liver transplantation, we conducted network pharmacology analysis.

Methods

GSE100155 was obtained from the GEO database, and the DEGs of liver transplantation were analyzed. The 2D structure of tacrolimus was obtained from the National Library of Medicine, and the pharmacophore model of tacrolimus was predicted using the online tool pharmmapper. Then a network of tacrolimus and target genes was constructed through network pharmacology, and visualization and GO enrichment analysis was performed through Cytoscape. In addition, we also analyzed the correlation between key genes and immune infiltrating cells. The data of G

SUBMITTER: Chen L 

PROVIDER: S-EPMC7938157 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature