Plasma Cytokine Profiling to Predict Steroid Resistance in Pediatric Nephrotic Syndrome.

ABSTRACT:

Introduction

Glucocorticoids (GCs) are the primary treatment for nephrotic syndrome (NS), although ∼10% to 20% of children develop steroid-resistant NS (SRNS). Unfortunately, there are no validated biomarkers able to predict SRNS at initial disease presentation. We hypothesized that a plasma cytokine panel could predict SRNS at disease presentation, and identify potential pathways regulating SRNS pathogenesis.

Methods

Paired plasma samples were collected from 26 children with steroid-sensitive NS (SSNS) and 14 with SRNS at NS presentation and after ∼7 weeks of GC therapy, when SSNS versus SRNS was clinically determined. Plasma cytokine profiling was performed with a panel of 27 cytokines.

Results

We identified 13 cytokines significantly different in Pretreatment SSNS

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC7938200 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature