Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults.

ABSTRACT:

Objective

We examined the relation between serum-free testosterone and asthma, wheeze, asthma hospitalisations and lung function in older adults.

Design

Cross-sectional study.

Setting

UK.

Participants

256 419 adults aged 40 to 69 years, recruited from 2006 to 2010.

Main outcome measures

Multivariable logistic or linear regression was used for the analysis of free testosterone and physician-diagnosed asthma, current wheeze, asthma hospitalisations and lung function measures, which was adjusted for serum estradiol, smoking status and other covariates.

Results

Free testosterone levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma in both women (adjusted OR (aOR) for Q4 (the highest quartile) versus Q1=0.67, 95

SUBMITTER: Han YY 

PROVIDER: S-EPMC7938359 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature