Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis.

ABSTRACT:

Background

Adenomyosis (AM) is a common benign chronic gynaecological disorder; however, the precise pathogenesis of adenomyosis is still poorly understood. Single-cell RNA sequencing (scRNA-seq) can uncover rare subpopulations, explore genetic and functional heterogeneity, and reveal the uniqueness of each cell. It provides us a new approach to reveal biological issues from a more detailed and microscopic perspective. Here, we utilize this revolutionary technology to identify the changes of gene expression patterns between ectopic lesions and the eutopic endometrium at the single-cell level and explore a potential novel pathogenesis of AM.

Methods

A control endometrium (sample with leiomyoma excluding endometrial disorders, n = 1), eutopic endometrium and ectopic lesion (fr

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7938473 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature