An intriguing characteristic of enhancer-promoter interactions.

ABSTRACT:

Background

It is still challenging to predict interacting enhancer-promoter pairs (IEPs), partially because of our limited understanding of their characteristics. To understand IEPs better, here we studied the IEPs in nine cell lines and nine primary cell types.

Results

By measuring the bipartite clustering coefficient of the graphs constructed from these experimentally supported IEPs, we observed that one enhancer is likely to interact with either none or all of the target genes of another enhancer. This observation implies that enhancers form clusters, and every enhancer in the same cluster synchronously interact with almost every member of a set of genes and only this set of genes. We perceived that an enhancer can be up to two megabase pairs away from other enhancers in

SUBMITTER: Talukder A 

PROVIDER: S-EPMC7938488 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature