Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight.

ABSTRACT:

Background

Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is causal.

Methods

We performed two-sample Mendelian randomization (MR) using summary data on associations between genotype-B12 (10 genetic variants) or genotype-folate (four genetic variants) levels from: a genome-wide association study of 45 576 individuals (sample 1); and both maternal- and fetal-specific genetic effects on offspring birthweight from the latest Early Growth Genetics consortium meta-analysis with 297 356 individuals reporting their own birthweight and 210 248 women reporting their offspring's birthweight (sample 2). We used the inverse variance

SUBMITTER: Moen GH 

PROVIDER: S-EPMC7938507 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature