Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children.

ABSTRACT:

Background

Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in monocytes occur with aging, though most studies to date have focused on differences between young adults and the elderly in populations with European ancestry; few data exist regarding changes that occur in circulating monocytes during the first few decades of life or in African populations. We analyzed DNA methylation profiles, cytokine production, and inflammatory gene expression profiles in monocytes from young adults and children from western Kenya.

Results

We identified several hypo- and hyper-methylated CpG sites in monocytes from Kenyan young adults vs. c

SUBMITTER: Dobbs KR 

PROVIDER: S-EPMC7938546 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature